テロメア - 最新の研究とニュース | ネイチャー

Telomeres - Latest research and news | Nature Skip to main content Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Advertisement Telomeres articles from across Nature Portfolio Atom RSS Feed Definition Telomeres are the ends of linear chromosomes. Telomeric DNA is bound by specialized proteins that prevent it from being targeted by DNA damage repair pathways, and is maintained by the enzyme telomerase. Latest Research and Reviews Highly mutagenic copying of telomeric circles promotes ALT establishment Alternative lengthening of telomeres (ALT) is a telomerase-independent pathway that enables cancer cells to maintain their telomeres. Here, using Oxford Nanopore sequencing, the authors uncover molecular milestones during ALT establishment in yeast and demonstrate that telomere extension proceeds through highly error prone copying of telomeric circles. Meng-Chia Tsai Jacob M. Wells Anna Malkova Research Open Access 22 Apr 2026 Nature Communications P: The adaptive molecular landscape of reprogrammed telomeric sequences The molecular mechanisms allowing organisms to adapt to new telomeric sequences remain poorly understood. Here, the authors engineer multiple yeast lines with human-like telomeric repeats to unveil their molecular and fitness response to reprogrammed telomeres, highlighting several adaptive measures. Melania D’Angiolo Benjamin P. Barré Gianni Liti Research Open Access 09 Apr 2026 Nature Communications P: Determinants of chromosome-specific telomere lengths among 2573 All of Us participants Telomere length varies across chromosome arms, but most studies measure only averages. Here, the authors use long‑read sequencing in >2,500 participants to map chromosome‑specific lengths, showing arm‑level variation, strong individual differences, and associations with aging and disease. Niyati Jain Jiajun Luo Brandon L. Pierce Research Open Access 28 Mar 2026 Nature Communications P: Nonsense-mediated mRNA decay safeguards telomeres in pluripotent stem cells Markiewicz-Potoczny et al. report that the nonsense-mediated mRNA decay pathway protects telomeres in the absence of core Shelterin component TRF2 by regulating the stability and abundance of TRF1 at telomeres. Marta Markiewicz-Potoczny Si Young Lee Eros Lazzerini Denchi Research Open Access 24 Mar 2026 Nature Cell Biology Volume: 28, P: 674-683 Both genome instability and replicative senescence stem from the shortest telomere in telomerase-negative cells In absence of telomerase, short telomeres trigger senescence. Here, the authors find using single-telomere-single-cell approaches in budding yeast, that one critically short telomere is required and sufficient to induce senescence. Some cells can escape via DNA rearrangements, trading stability for survival. Prisca Berardi Veronica Martinez-Fernandez Maria Teresa Teixeira Research Open Access 15 Mar 2026 Nature Communications P: Protection of telomeres 1b safeguards the Arabidopsis genome by regulating ROS homeostasis The authors uncover a noncanonical role for Arabidopsis POT1b in maintaining genome stability through ROS regulation, establishing an unexpected connection between telomere biology and cellular oxidative stress. Ji-Hee Min Claudia Castillo-González Dorothy E. Shippen Research Open Access 10 Mar 2026 Nature Communications Volume: 17, P: 3728 All Research & Reviews News and Comment High-resolution measurement of individual telomere lengths with Telo-seq In this Tools of the Trade article, Carly Tyer describes the development of Telo-seq, a method to enrich and sequence all telomeres within a sample, and highlights its use in distinguishing between the two telomere maintenance mechanisms used in cancer cells. Carly Tyer Research Highlights 22 Oct 2024 Nature Reviews Cancer Volume: 25, P: 76 Pharmacological TERT activation attenuates phenotypes of natural aging Hannah Walters Research Highlights 08 Jul 2024 Nature Aging Volume: 4, P: 904 The risky business of ADP-ribosylating telomeric DNA ADP-ribosylation regulates the activity of numerous proteins involved in the DNA damage response and repair. A new study shows that telomeric DNA can be ADP-ribosylated by PARP1, and prompt removal of the ADP-ribose by TARG1 is essential to preserve telomere integrity, unveiling DNA–ADP-ribosylation as a novel player in telomere stability. Ylli Doksani Francisca Lottersberger News & Views 07 May 2024 Nature Structural & Molecular Biology Volume: 31, P: 737-738 All roads lead to MRN regulation at telomeres: different paths to one solution New work shows that in mammals, the iDDR motif of telomere factor TRF2 inhibits the MRE11–RAD50–NBS1 (MRN) complex at chromosome ends through a direct iDDR–RAD50 interaction. Unrelated protein motifs in yeasts inhibit MRN functions via an analogous mechanism, suggesting a convergent evolution in eukaryotes to control MRN action at telomeres. Florian Roisné-Hamelin Stéphane Marcand News & Views 31 Aug 2023 Nature Structural & Molecular Biology Volume: 30, P: 1242-1243 A nascent interest amplified Thoru Pederson recalls the impact that a 1968 paper from Dan Brown’s lab had on his career. Thoru Pederson Research Highlights 13 Apr 2023 Nature Reviews Molecular Cell Biology Volume: 24, P: 453 RPA dynamics at telomeres Self-assembly of replication protein A (RPA) into dynamic condensates after binding of single-stranded DNA promotes telomere maintenance in cancer cells. Eytan Zlotorynski Research Highlights 31 Mar 2023 Nature Reviews Molecular Cell Biology Volume: 24, P: 310 All News & Comment Search Search articles by subject, keyword or author Show results from All journals Search Advanced search Quick links Explore articles by subject Find a job Guide to authors Editorial policies