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Blisters | MedlinePlus Skip navigation Official websites use .gov A .gov website belongs to an official government organization in the United States. Secure .gov websites use HTTPS A lock ( Lock Locked padlock icon ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites. You Are Here: Home → Health Topics → Blisters URL of this page: https://medlineplus.gov/blisters.html Blisters Also called: Bulla, Vesicle Summary What are blisters? Blisters are fluid-filled sacs on the outer layer of your skin. They form because of rubbing, heat, or diseases of the skin. They are most common on your hands and feet. Other names for blisters are vesicles (usually for smaller blisters) and bulla (for larger blisters). What causes blisters? Blisters often happen when there is friction - rubbing or pressure - on one spot. For example, if your shoes don't fit quite right and they keep rubbing part of your foot. Or if you don't wear gloves when you rake leaves and the handle keeps rubbing against your hand. Other causes of blisters include: Burns Sunburn Frostbite Eczema Allergic reactions Poison ivy, oak, and sumac Autoimmune diseases such as pemphigus Epidermolysis bullosa, an illness that causes the skin to be fragile Viral infections such as varicella zoster (which causes chickenpox and shingles ) and herpes simplex (which causes cold sores ) Skin infections including impetigo What are the treatments for blisters? Blisters will usually heal on their own. The skin over the blister helps keep out infections. You can put a bandage on the blister to keep it clean. Make sure that there is no more rubbing or friction on the blister. You should contact your health care provider if: The blister looks infected - if it is draining pus, or the area around the blister is red, swollen, warm, or very painful You have a fever You have several blisters, especially if you cannot figure out what is causing them You have health problems such as circulation problems or diabetes Normally you don't want to drain a blister, because of the risk of infection. But if a blister is large, painful, or looks like it will pop on its own, you can drain the fluid. Can blisters be prevented? There are some things you can do to prevent friction blisters: Make sure that your shoes fit properly Always wear socks with your shoes, and make sure that the socks fit well. You may want to wear socks that are acrylic or nylon, so they keep moisture away from your feet. Wear gloves or protective gear on your hands when you use any tools or sports equipment that cause friction. Learn More Blisters (For Kids) (Nemours Foundation) Also in Spanish Blisters, First Aid (VisualDX) Blisters: First Aid (Mayo Foundation for Medical Education and Research) Also in Spanish How To Prevent and Treat Blisters (American Academy of Dermatology) Vesicles (Medical Encyclopedia) Also in Spanish Clinical Trials ClinicalTrials.gov: Blister (National Institutes of Health) Journal Articles References and abstracts from MEDLINE/PubMed (National Library of Medicine) Article: A First-In-Human Randomized Controlled Phase 1 Study Assessing the Safety and... Article: Efficacy and cost-effectiveness of VATS versus chest tube drainage in first-episode... Article: Diagnostic Agreement in Subepidermal Blistering Diseases: Is ELISA Test Reliable as... Blisters -- see more articles Topic Image Disclaimers MedlinePlus links to health information from the National Institutes of Health and other federal government agencies. MedlinePlus also links to health information from non-government Web sites. See our disclaimer about external links and our quality guidelines . The information on this site should not be used as a substitute for professional medical care or advice. Contact a health care provider if you have questions about your health. Learn how to cite this page